Polymeric Mixed-Micelles for Nanomedicine Applications

Some work I performed as a scientist at IBM Almaden Research Center: A degradable polymeric mixed-micelle system based on amphiphilic mPEG-b-polycarbonate diblock copolymers was developed. This mussel-inspired polymer design features catechol side chains to which the anticancer drug doxorubicin (DOX) can be covalently conjugated as pH-sensitive p-quinoneimines via a mechanism that mimics the Raper–Mason pathway of mammalian melanogenesis.

  

Article link:  http://pubs.acs.org/doi/abs/10.1021/acs.macromol.5b02784

Metal-Free MRI Contrast Agents - a Radical Solution!

My paper on organic radical-functionalized polymers has just been published in ACS Macro Letters. This was work that was done 2 years ago at IBM Almaden Research Center. The idea behind this research was to employ a metal-free spin-active system that is also biodegradable. Our work on these radical-functionalized diblock copolymers can be accessed here: ACS Macro Lett. 2017, 6, 176-180.

Accompanying patent application: Chan, et al. “Biodegradable Organic Radical-Functionalized Polycarbonates for Medical Applications”, U.S. Patent App. 14/609,778, 2015.